NCT04018144

Running Title: PPAR-γ, RXR-α, and VDR Expressions in Periodontitis

PPAR-γ, RXR-α, and VDR Expressions in Periodontitis Patients With Different Stage and Grade Involvement

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 45 (estimated)
• Sponsor: Tokat Gaziosmanpasa University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Objective: The present study aimed to determine the expressions of nuclear receptors PPAR (Peroxisome proliferative activator receptor)-γ, RXR (Retinoid X receptor)-α, and vitamin D receptor (VDR) in healthy volunteers and periodontitis patients with different grade involvement. Methods: Group-1; healthy individuals, Group-2; periodontitis patients-stage 3 grade B, (H-GradeB), Group-3; periodontitis patients-stage 3 grade C, (D-GradeC). Clinical parameters as plaque index (PI), gingival index (GI) and clinical attachment levels (CAL) were measured. Fibroblast and inflammatory cells, PPAR-γ, RXR-α, and VDR levels were determined in histological slides.

Conditions

• Periodontitis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Gingiva Biopsy Sampling	Gingival samples of healthy individuals were collected by gingivectomy or crown lengthening procedure in the routine treatment protocol or before orthodontically indicated tooth extraction. Gingival samples of periodontitis patients were obtained during the scaling and root planning procedure. Posterior maxillary teeth (#4, #5, #6, and #7) were chosen for gingival sampling.

Timeline

• Start date: 2019-08-01
• Primary completion: 2019-12-01
• Completion: 2020-03-01
• First posted: 2019-07-12
• Last updated: 2019-07-12

Locations

1 site across 1 country: Turkey (Türkiye)