NCT04017039

Sleep, Blood Pressure and Vascular Health

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 107 (actual)
• Sponsor: University of Colorado, Boulder · Academic / Other
• Sex: All
• Age: 45 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The investigators hypothesize that chronic insufficient sleep is associated with diminished endothelium-dependent nitric oxide-mediated vasodilation and endothelial tissue-type plasminogen activator release in adults with elevated blood pressure. Furthermore, the investigators hypothesize that the postulated diminishment in endothelial vasodilator and fibrinolytic function with insufficient sleep will be due, at least in part, to increased oxidative stress. Furthermore, increasing sleep duration and improving sleep quality will increase both endothelium-dependent nitric oxide-mediated vasodilation and endothelial tissue-type plasminogen activator release in adults with elevated blood pressure. Increases in endothelial vasodilator and fibrinolytic function will be due, at least in part, to reduced oxidative stress.

Conditions

• Blood Pressure
• Sleep

Interventions

Type	Name	Description
OTHER	Targeted Sleep Intervention

Timeline

• Start date: 2016-11-10
• Primary completion: 2021-11-01
• Completion: 2023-05-01
• First posted: 2019-07-12
• Last updated: 2023-11-30

Locations

1 site across 1 country: United States