NCT04010487

Multi-omics Study on the Pathogenesis of Malignant Transformation of Adenomyosis

A Multi-omics Study on the Pathogenesis of Malignant Transformation of Adenomyosis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Lei Li · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is to explore the driving genes and the molecular mechanism of malignant transformation of adenomyosis. This study acquired the formalin fixed paraffin-embedded (FFPE) tissue of patients pathologically conformed endometrial carcinoma arising in adenomyosis (EC-AIA) treated at Peking Union Medical College Hospital from July 15, 2017 to July 15, 2019. The formalin fixed paraffin-embedded tissues from patients pathologically diagnosed with adenomyosis during this time period were also included as control specimens. The eutopic endometrium, normal adenomyosis tissue, and EC-AIA tissue were harvested from the FFPE tissue from patients with EC-AIA. The normal eutopic endometrium and normal adenomyosis tissue were obtained by laser microdissection. The driving genes and potential molecular mechanism of EC-AIA will be found by the technology of whole exome sequencing and transcriptomics (RNA-sequencing).

Conditions

• Adenomyosis
• Endometrial Cancer
• Ectopic Endometrial Tissue
• Eutopic Endometrium
• Genomics
• Transcriptomics

Interventions

Type	Name	Description
GENETIC	whole exome sequencing and RNA-sequencing	The specimens from adenomyosis, endometrial cancer, and eutopic endometrium will be tested by whole exome sequencing and RNA-sequencing

Timeline

• Start date: 2019-07-16
• Primary completion: 2021-08-01
• Completion: 2021-08-01
• First posted: 2019-07-08
• Last updated: 2019-07-18

Locations

1 site across 1 country: China