NCT04008147

Hepcidin and Glucose Metabolism

The Effect of Oral Iron Supplements on Hepcidin, Insulin and Glucose Metabolism in Pregnancy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Swiss Federal Institute of Technology · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Gestational diabetes mellitus (GDM), defined as hyperglycemia with blood glucose values above normal but below those diagnostic of DM, and iron deficiency (ID) with or without anemia (IDA) are common during pregnancy. Both disease patterns are associated with an increased risk of complications during pregnancy and at delivery and may have a variety of negative effects on different aspects of child development. Thus, GDM and ID/IDA during pregnancy should be prevented. Whether iron supplementation with high oral doses acutely increases hepcidin during pregnancy, and whether this acute iron-induced increase in hepcidin decreases insulin sensitivity, is uncertain.

Conditions

• Iron Deficiency Anemia of Pregnancy
• Iron Metabolism Disorders
• Glucose Intolerance
• Gestational Diabetes

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	100mg iron fumarate	100mg iron fumarate b.i.d. for 4 consecutive days
DIETARY_SUPPLEMENT	Burgerstein Schwangerschaft & Stillzeit	contains 30 mg iron fumarate, given on 14 consecutive days

Timeline

• Start date: 2019-07-03
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2019-07-05
• Last updated: 2025-05-22

Locations

1 site across 1 country: Switzerland