NCT04006249

Haemochromatosis and Periodontitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 87 (actual)
• Sponsor: Rennes University Hospital · Academic / Other
• Sex: All
• Age: 35 Years – 64 Years
• Healthy volunteers: Not accepted

Summary

Periodontitis is a chronic inflammatory disease that affects tissues surrounding the teeth. It is strongly associated with the major pathogenic "red complex", including Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola1 and thus is considered an infection. Recent advances in the pathogenesis of periodontal disease have suggested that polymicrobial synergy and microbiota dysbiosis together with a dysregulated immune response can induce inflammation-mediated damage in periodontal tissues2-4. Interestingly, currently periodontitis is associated with a growing number of systemic diseases, including cardiovascular diseases, adverse pregnancy outcomes, diabetes5-7 and hereditary haemochromatosis8.

Conditions

• to Evaluate the Prevalence of Periodontal Diseases in Patients With Hemochromatosis at the Time of Diagnosis and / or Their Usual Therapeutic

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	dental probes	Measurement of the depth of the periodontal pockets and clinical loss

Timeline

• Start date: 2010-06-06
• Primary completion: 2011-09-22
• Completion: 2011-12-01
• First posted: 2019-07-05
• Last updated: 2019-07-05