NCT04005742

The Biomarkers Of RIsk of Colorectal Cancer (BORICC) Follow-Up (BFU) Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 47 (actual)
• Sponsor: Newcastle University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Worldwide, colorectal cancer is the 3rd most common cancer; risk increases with age and is modified by lifestyle factors notably diet, physical activity and obesity. The BORICC Follow-Up (BFU) Study is a 12+ year follow-up of participants recruited to the Biomarkers of Risk of Colon Cancer (BORICC) Study. This longitudinal study will investigate associations between ageing and lifestyle factors and a panel of molecular biomarkers linked with colorectal cancer risk.

Detailed description

The BORICC Follow-Up (BFU) Study builds on the findings from the BORICC Study where the investigators observed associations between age and nutritional factors, including selenium and folate, and biomarkers of colorectal health. The BFU Study will investigate the relationships between ageing (12+ years) and such biomarkers longitudinally. It is anticipated that the project will produce novel data on (i) changes in biomarkers of colorectal cancer risk with age and (ii) the effects of obesity and lifestyle factors on biomarkers of colorectal cancer risk. These biomarkers include differentially expressed proteins, DNA methylation markers and inflammation markers.

Conditions

• Colorectal Cancer

Timeline

• Start date: 2017-03-13
• Primary completion: 2018-06-08
• Completion: 2018-06-08
• First posted: 2019-07-02
• Last updated: 2019-07-02

Locations

1 site across 1 country: United Kingdom