NCT04004715

Effects of Protein Quality on Post-exercise Skeletal Muscle and Whole-body Protein Kinetics During Energy Deficit

Effects of Protein Quality on Post-exercise Skeletal Muscle and Whole-body Protein Kinetics During Negative Energy Balance

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: United States Army Research Institute of Environmental Medicine · Federal
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The optimal EAA-containing protein format necessary to maximally stimulate muscle protein synthesis and optimize whole-body net protein balance during caloric deprivation has not been determined. This study will address that gap in knowledge by examining post, whole-body exercise muscle and whole-body protein kinetic responses to ingesting varying EAA-containing protein formats after a 5 day period of negative energy balance. This study will provide the initial evidence to support the development of a recovery-based food product for military combat rations.

Detailed description

Ten resistance-trained adults will complete this \~55-d randomized, cross-over study. Participants will participate in three, non-consecutive 5-d controlled energy deficit periods, each separated by a 14-d washout period (i.e., sufficient time to restore nitrogen and metabolic homeostasis after moderate weight loss). Post-exercise (whole-body exercise model) muscle protein synthesis (MPS) and whole-body protein turnover responses to varying EAA-containing protein formats will be determined the morning after completing the 5-d energy deficit.

Conditions

• Whole-body Protein Balance
• Muscle Protein Synthesis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Essential Amino Acid Enriched Whey Protein	protein powder formulation that includes whey and free-form essential amino acids
DIETARY_SUPPLEMENT	Whey Protein	commercially available whey protein isolate
DIETARY_SUPPLEMENT	Military Ration Entree	chili and beans entree; current meal component of the meals ready to eat rations

Timeline

• Start date: 2019-04-25
• Primary completion: 2019-12-13
• Completion: 2019-12-13
• First posted: 2019-07-02
• Last updated: 2020-03-12

Locations

1 site across 1 country: United States