NCT04001465

Determining Baseline Respiratory Duty Cycles in Subjects With and Without Airway Hyperresponsiveness

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: University of Saskatchewan · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The study investigates the inspiratory duty cycle in subjects with and without airway hyper-responsiveness both at rest and during a bronchoprovocation challenge. The primary goal is to determine an average inspiratory duty cycle for standard use in the calculation of bronchoprovocation test results.

Detailed description

At least fifteen subjects with airway hyper-responsiveness and fifteen without airway hyper-responsiveness will be recruited to participate in this randomized, crossover study. Subjects will complete 2 methacholine challenges at least 24 hours apart. One methacholine challenge will entail the volumetric method using a vibrating mesh nebulizer. The second methacholine challenge will be performed identically except that the nebulizer will be fitted onto an ultrasonic nebulizer so as to measure the inspiratory duty cycle throughout the bronchoprovocation challenge.

Conditions

• Airway Hyper Responsiveness

Interventions

Type	Name	Description
PROCEDURE	Volumetric methacholine challenge unmodified	Bronchoprovocation challenge performed per volumetric method
PROCEDURE	Modified volumetric methacholine challenge	Bronchoprovocation challenge performed per volumetric method modified to include use of ultrasonic spirometer fitted with vibrating mesh nebulizer

Timeline

• Start date: 2019-05-14
• Primary completion: 2019-06-30
• Completion: 2019-06-30
• First posted: 2019-06-28
• Last updated: 2020-03-27

Locations

1 site across 1 country: Canada