NCT04000061

Heart Failure-USB: Prediction and Progression

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 6,000 (estimated)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This retrospective cohort study is to identify triggers of heart failure (HF) development and drivers of HF progression as well as the underlying cardiac disease (phenotype) to identify patients at risk and predict the clinical course of the disease. Data of patients who were hospitalized during the years 2010-2023 with acute coronary syndrome (ACS) and/ or with acute heart failure (AHF) will be collected and analyzed. In a subgroup cohort efficacy and safety of digoxin in patients with acute heart failure triggered by tachyarrhythmia will be evaluated.

Conditions

• Acute Heart Failure
• Acute Coronary Syndrome
• Heart Failure

Interventions

Type	Name	Description
OTHER	medical chart review	data generated by medical review include Medical history, Medications at presentation, during hospitalization and at discharge, New York Heart Association (NYHA) class, Killip class, Electrocardiographic (ECG) data, echocardiographic data, Interventions (Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Graft (CABG), Implantable Cardioverter Defibrillator (ICD) implantation, Cardiac Resynchronization Therapy (CRT) Implantation), Outcome Information: all-cause death, HF hospitalizations
OTHER	data generated by direct IT export	data generated by direct IT export include Anthropometric data (age, sex, height, weight), Vital signs, Laboratory data

Timeline

• Start date: 2019-06-13
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2019-06-27
• Last updated: 2025-04-10

Locations

1 site across 1 country: Switzerland