Trials / Withdrawn
WithdrawnNCT03998917
Pathophysiological Characterization of the Neuromuscular Function of a Population With Multiple Comorbidities Suffering From Chronic Renal Failure in Pre-dialysis.
- Status
- Withdrawn
- Phase
- —
- Study type
- Observational
- Enrollment
- 0 (actual)
- Sponsor
- Centre Hospitalier le Mans · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The evolution of chronic kidney disease (CKD) causes a systemic upheaval on the body and a deep fatigue is very often described by patients (50-70% of the patients) even before the start of dialysis (pre-dialysis). This fatigue has many origins, and one of them probably stems from a deterioration of neuromuscular abilities. Very few studies have examined the physiological aspects of neuromuscular fatigue in pre-dialysis patients, and shedding light on potential deficits at this level would allow safe and efficient implementation of adapted physical activity programs. Our study aims to characterize the pathophysiology of neuromuscular capabilities in chronic advanced renal failure in pre-dialysis patients.
Conditions
- Chronic Kidney Failure
- Chronic Kidney Disease stage3
- Chronic Kidney Disease, Stage 4 (Severe)
- Chronic Kidney Disease Stage 5
- Fatigue
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Discrimination of neuromuscular alterations protocol | Patients will perform a hand grip fatigability test with their dominant hand, followed by a Timed Up and Go Test (TUG-Test), a Five-repetition sit-to-stand-test (5STS-Test) and a10 meters gait speed test. |
Timeline
- Start date
- 2019-09-01
- Primary completion
- 2020-09-01
- Completion
- 2020-12-31
- First posted
- 2019-06-26
- Last updated
- 2020-03-25
Source: ClinicalTrials.gov record NCT03998917. Inclusion in this directory is not an endorsement.