NCT03998826

Piroxicam Premedication for Postendodontic Pain in Non-vital Mandibular Molars

Effect of Piroxicam Premedication on Postendodontic Pain in Mandibular Molars With Non-vital Pulp: A Randomized Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to evaluate the effect of piroxicam (20mg) compared to placebo on post-endodontic pain of single-visit endodontic treatment of non-vital mandibular molars.

Detailed description

* Patients will be clinically and radiographically examined and their eligibility will be assessed. Eligible patients will be treated in one visit. * Patients will be randomly assigned to one of 2 groups: experimental group (premedication with 20 mg of piroxicam) and the control group (premedication with placebo). Each participant will receive a standard inferior alveolar nerve block injection. After endodontic treatment, patients will be given postoperative instructions and informed, in case of pain, to receive ibuprofen 200 mg as rescue medication. * Postendodontic pain intensity and incidence at the different pain categories (No, mild, moderate, severe) will be assessed 6, 12, 24, 48, 72 hours and 7 days postoperatively using a 0-10 numerical rate scale (NRS). Analgesic intake throughout the 7 days will be recorded.

Conditions

• Non-Vital Tooth

Interventions

Type	Name	Description
DRUG	Piroxicam	20mg piroxicam
DRUG	Placebo	placebo

Timeline

• Start date: 2019-09-01
• Primary completion: 2020-09-01
• Completion: 2020-12-01
• First posted: 2019-06-26
• Last updated: 2019-07-16