NCT03996824

Study of Viral Transduction of Human Auditory Sensory Cells for the Development of Gene Therapy

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Institut Pasteur · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models. This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.

Conditions

• Hearing Loss, Sensorineural

Interventions

Type	Name	Description
OTHER	Peroperative collect of inner ear cells	After obtaining an informed consent during the preoperative medical visit, and if a non-conservative approach (translabyrinthine or transotic) is decided, the collect of inner ear cells will be performed during surgical approach. The sample will be collect in a sterile tube, and carried to the laboratory were it will be placed bon cell culture.

Timeline

• Start date: 2019-02-19
• Primary completion: 2027-02-18
• Completion: 2027-02-18
• First posted: 2019-06-25
• Last updated: 2024-09-19

Locations

2 sites across 1 country: France