NCT03996018

T-cell Responses to Concurrent HIV and Herpesvirus Infections

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 135 (actual)
• Sponsor: St. Jude Children's Research Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a research study in which we are trying to discover new information about how HIV and herpes viruses interact with the immune system. The goal of the study is to learn more about how T-cells in your immune system respond to and fight off long-term (chronic) viruses, in order to improve medical care in the future.

Detailed description

HIV-uninfected \& HIV-infected participants who enroll on this study will be asked to provide blood samples for 18 months. These samples will be used to assess T-cell responses and presence of herpesvirus(es). Primary Objective Characterize phenotypic and functional features, including TCR repertoires of HIV-specific CD8 T-cell responses and exhaustion in HIV-positive humans with and without concomitant herpesvirus infections.

Conditions

• HIV
• HIV Infections

Interventions

Type	Name	Description
OTHER	T-cell lymphocyte responses	T-cell lymphocyte responses to human immunodeficiency virus (HIV) with and without concomitant herpesvirus infections (specifically, the persistence of HIV-specific human CD8 T-cells in the context of antiretroviral therapy (ART).

Timeline

• Start date: 2019-06-19
• Primary completion: 2023-07-28
• Completion: 2023-07-28
• First posted: 2019-06-24
• Last updated: 2024-11-15

Locations

1 site across 1 country: United States