NCT03990922

CTPVB for Hepatectomy

Continuous Thoracic Paravertebral Block for Open Hepatectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 76 (actual)
• Sponsor: Cui Xulei · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Moderate to severe postoperative pain often influence patients quality of recovery after hepatectomy. Systemic opioids given with patient-controlled analgesia has been used after hepatectomy in many medical center, but the analgesic effect can be limited and undesirable side effects may bring about negative effects on patients recovery. Regional block has been proved to improve patients postoperative recovery in many kinds of surgeries. The investigators therefore designed a prospective, randomized, subject and assessor blinded, parallel-group, placebo controlled study to test the hypothesis that continuous right thoracic paravertebral block increase patients quality of recovery score on the 7th postoperative day after hepatectomy in patients receiving i.v. patient-controlled analgesia (PCA) with morphine.

Conditions

• Pain Management
• Paravertebral Block
• Hepatectomy

Interventions

Type	Name	Description
PROCEDURE	Continuous Paravertebral block with ropivacaine	Inject 25 ml 0.5% ropivacaine in the T8 paravertebral space followed with catheter insertion and continuous 0.2% ropivacaine infusion(infusion rate: 0.125ml/kg/pulse,1pulse/h).
PROCEDURE	Continuous Paravertebral "block" with saline	Inject 25 ml 0.9% saline in the T8 paravertebral space followed with catheter insertion and continuous 0.9% ropivacaine infusion(infusion rate: 0.125ml/kg/pulse,1pulse/h).
DRUG	Patient-controlled analgesia with morphine	Morphine given as intravenous patient-controlled analgesia bolus: 2mg, lock time: 5min, 1h limitation: 8mg

Timeline

• Start date: 2019-06-20
• Primary completion: 2019-11-09
• Completion: 2019-11-17
• First posted: 2019-06-19
• Last updated: 2020-01-02

Locations

1 site across 1 country: China