Trials / Completed
CompletedNCT03990766
Smell Changes & Efficacy of Nasal Theophylline
SCENT Trial: Nasal Theophylline Irrigation for Treatment of Post-Viral Olfactory Dysfunction
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 27 (actual)
- Sponsor
- Washington University School of Medicine · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
This study evaluates the efficacy and safety of nasal theophylline irrigation in treating smell loss related to a viral respiratory infection. Half the participants will undergo nasal theophylline irrigation treatment while the other half will undergo placebo nasal irrigation with saline alone. All participants will have their sense of smell tested before and after 6 weeks of treatment. All participants will also be regularly asked about any potential side effects related to treatment. In addition, the first 10 participants will have their blood drawn to measure their theophylline level after 1 week of starting treatment to ensure it is not abnormally elevated.
Conditions
- Olfactory Disorder
- Anosmia
- Viral Infection
- Theophylline Causing Adverse Effects in Therapeutic Use
- Smell Disorder
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Theophylline | Theophylline delivered via high-volume, low-pressure nasal saline irrigation |
| DRUG | Saline Nasal | Lactose delivered via high-volume, low-pressure nasal saline irrigation |
Timeline
- Start date
- 2019-05-15
- Primary completion
- 2021-01-15
- Completion
- 2021-01-15
- First posted
- 2019-06-19
- Last updated
- 2022-03-31
- Results posted
- 2022-03-31
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT03990766. Inclusion in this directory is not an endorsement.