NCT03990623

CT Perfusion Scans in Detecting Changes in Blood Flow to the Liver After Portal Vein Embolization

To Evaluate Perfusion Changes to the Liver Following Pre-Operative Portal Vein Embolization for Patients With Liver Cancer

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (estimated)
• Sponsor: M.D. Anderson Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This trial studies the use of computed tomography (CT) perfusion scans in detecting changes in blood flow to the liver after portal vein embolization in patients with liver cancer. CT perfusion scans use a standard contrast drug given by vein to measure blood flow to the liver. CT perfusion scans may predict the rate and amount of growth of new, healthy tissue on one side of the liver after a portal vein embolization and detect change to the size of the liver tumor as result of the procedure.

Detailed description

PRIMARY OBJECTIVES: I. To assess whether perfusion changes to the liver following portal vein embolization (PVE) correlate with hypertrophy of the future liver remnant (FLR). SECONDARY OBJECTIVES: I. To assess perfusion changes to liver tumors following PVE. II. To assess whether PVE may affect tumor growth. OUTLINE: Prior to PVE, patients undergo CT perfusion scan of the liver and liver biopsy over 15 minutes. Patients undergo a second CT perfusion scan immediately after PVE and a third CT perfusion scan 3-6 weeks post PVE.

Conditions

• Liver and Intrahepatic Bile Duct Carcinoma

Interventions

Type	Name	Description
RADIATION	Computed Tomography Perfusion Imaging	Undergo perfusion CT
PROCEDURE	Liver Biopsy	Undergo liver biopsy

Timeline

• Start date: 2018-07-21
• Primary completion: 2024-04-30
• Completion: 2024-04-30
• First posted: 2019-06-19
• Last updated: 2023-04-07

Locations

1 site across 1 country: United States