NCT03990181

Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement

Testing the Efficacy of a Natural Polyphenol Supplement to Inhibit Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis: a Stable Isotope Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Swiss Federal Institute of Technology · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Polyphenolic compounds are very strong Inhibitors of non-heme iron absorption, as they form insoluble complexes with ferrous iron. Patients with hereditary hemochromatosis (HH) have an increased intestinal non-heme iron absorption due to a genetic mutation in the regulatory pathway, leading to excess iron in the body. This study investigates the inhibitory effect of a natural polyphenol Supplement in participants with HH.

Conditions

• Iron Metabolism Disorders
• Iron Overload
• Polyphenols

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	meal matrix & NPPS	Test meal consumed with the natural polyphenol supplement
DIETARY_SUPPLEMENT	meal matrix & CS	Test meal consumed with the control supplement
DIETARY_SUPPLEMENT	no-matrix & NPPS	Test drink consumed with the natural polyphenol supplement
DIETARY_SUPPLEMENT	no-matrix & CS	Test drink consumed with the control supplement

Timeline

• Start date: 2019-09-20
• Primary completion: 2020-08-15
• Completion: 2020-08-15
• First posted: 2019-06-18
• Last updated: 2021-05-26

Locations

2 sites across 2 countries: Portugal, Switzerland