NCT03989258

Personalised Risk-based Breast Cancer Prevention and Screening

Implementation of a Model for Personalised Risk-Based Breast Cancer Prevention and Screening

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 28,389 (estimated)
• Sponsor: Tartu University Hospital · Academic / Other
• Sex: Female
• Age: 25 Years
• Healthy volunteers: Not accepted

Summary

This is a cohort study, applied research and T3 translational genomics to estimate the impact of genetic risk for breast cancer detection in the screening program. The study group base consists of 28 389 female participants, currently in the age-group 22-79, in the Biobank of Estonian Genome Centre. The study is aimed to demonstrate the usability of personalised approach for adjusting and stratifying screening recommendations, based on predicted genetic risk estimates for breast cancer in the situation, where the genome data could be available from all women who have given informed consent for that. The project includes both the detection of moderate and high hereditary breast cancer risk carriers as well as high risk polygenic risk-score (consisting several single nucleotide polymorphisms) carriers among healthy individuals for application of personalised prevention and screening strategies.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Mammography outside official screening	Radiologic study

Timeline

• Start date: 2018-10-01
• Primary completion: 2020-12-01
• Completion: 2020-12-01
• First posted: 2019-06-18
• Last updated: 2019-06-20

Locations

2 sites across 1 country: Estonia