NCT03988998

Radiofrequency Ablation Plus Radiotherapy for Small Hepatocellular Carcinoma

radioFrequency Ablation With or Without RadioTherapy for Small HEpatocellulaR Carcinoma: a Randomized Control Trial

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Guangxi Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Radiofrequency ablation (RFA) and hepatic resection are main treatments for early stage hepatocellular carcinoma. Many randomized controlled trials found these two treatments have similar short term overall survival. However, hepatic resection is associated with higher long-term overall survival. These results reveal that tumor recurrence rate after RFA is higher than that after hepatic resection. And minimal residual tumor may exist after RFA. Radiotherapy after RFA may be effective to prevent early tumor recurrence.

Conditions

• Hepatocellular Carcinoma

Interventions

Type	Name	Description
DRUG	Radiofrequency ablation with radiotherapy	Radiofrequency ablation with radiotherapy
DRUG	Radiofrequency ablation alone	Radiofrequency ablation without radiotherapy

Timeline

• Start date: 2022-01-10
• Primary completion: 2022-12-31
• Completion: 2023-01-31
• First posted: 2019-06-18
• Last updated: 2022-01-18