NCT03987568

Characterize Tumor Hypoxia by Magnetic Resonance Imaging

To Characterize Tumor Hypoxia by Magnetic Resonance Imaging in African American and Caucasian Prostate Cancer Patients

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Wake Forest University Health Sciences · Academic / Other
• Sex: Male
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research study is to measure the hypoxia (low oxygen condition) in prostate cancers and its effect in survival. In this study, investigators will assess hypoxia by magnetic resonance imaging (MRI) and create a hypoxia score. Investigators will study the hypoxia score and how it correlates (if any) to the disease aggressiveness as well as its effect on the treatment outcomes.

Detailed description

Primary Objective(s): * To assess hypoxia in primary prostate tumors by magnetic resonance imaging. * To correlate hypoxic score with disease aggressiveness (proliferation biomarkers' expression). Secondary Objective(s): * To correlate hypoxic score with ExoHypoxic concentration in plasma of same patient. * To correlate hypoxic score with fatty acid synthase (FASN) expression.

Conditions

• Prostate Cancer
• Prostate Tumor

Interventions

Type	Name	Description
OTHER	Blood draws	Blood draws at two specified timepoints - the first is during the MRI and the second is scheduled during participant's prostatectomy.
DIAGNOSTIC_TEST	Magnetic resonance imaging (MRI)	At the beginning of study magnetic resonance imaging MRI will be completed.

Timeline

• Start date: 2019-07-10
• Primary completion: 2021-11-15
• Completion: 2021-11-15
• First posted: 2019-06-17
• Last updated: 2022-12-21

Regulatory

• FDA-regulated device study