NCT03979625

Prognosis Related to Induced Thrombopenia With Heparin Under Venoarterial ECMO in Reanimation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 39 (actual)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Thrombocytopenia is a frequent and serious adverse event in patients treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock. Similarly to postcardiac surgery patients, heparin-induced thrombocytopenia (HIT) could represent the causative underlying mechanism. However, the epidemiology as well as related mortality regarding HIT and VA-ECMO remains largely unknown. The investigators aimed to define the prevalence and associated 90-day mortality of HIT diagnosed under VA-ECMO.This retrospective study included patients under VA-ECMO from 20 French centers between 2012 and 2016.

Conditions

• Heparin-induced Thrombocytopenia

Interventions

Type	Name	Description
OTHER	Hospitalization for more than 3 days with high clinical suspicion of HIT and positive anti-PF4/heparin antibodies	Patients are classified according to results of functional tests as having either Confirmed or Excluded HIT.

Timeline

• Start date: 2016-01-01
• Primary completion: 2018-04-30
• Completion: 2018-04-30
• First posted: 2019-06-07
• Last updated: 2019-06-07