NCT03979105

Cardiovascular Safety After Continuous Ketamine Infusion

Cardiovascular and Neuropsychiatric Side Effects in Ketamine Analgesic Infusions in Acute Pain

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 300 (actual)
• Sponsor: Universidad de Antioquia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Observational study that evaluate the cardiovascular and neuropsychiatric side effects of ketamine analgesic infusions for acute pain

Detailed description

Severe acute pain and opioid tolerance is an important symptom in patients after surgery. Ketamine in analgesic infusion has been described to decrease acute pain, in patients with opioid tolerance. Ketamine use has been associated with side effects, which are doses dependant. Those side effects are mainly cardiovascular: Hypertension, tachycardia, and neuropsychiatric: delirium, hallucinations,nightmares that potentially compromise recovery of patients. Objective: To determine retrospectively in data bases the frequency of tachycardia, hypertension, delirium, hallucinations and nightmares, in adult patients that received ketamine infusions before and after administration of this drug in the first 48 hours to treat acute and postoperative pain

Conditions

• Pain
• Ketamine Adverse Reaction
• Postoperative Pain

Interventions

Type	Name	Description
DRUG	Ketamine	Drug: Ketamine Side effects associated with ketamine infusion to treat acute pain, were reviewed after 48 hours of exposure and frequency of tachycardia, hypertension, hallucinations, delirium and nightmares were registrated for comparison

Timeline

• Start date: 2017-07-01
• Primary completion: 2018-11-01
• Completion: 2018-12-31
• First posted: 2019-06-07
• Last updated: 2019-06-07

Locations

2 sites across 1 country: Colombia