Trials / Terminated
TerminatedNCT03976544
Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients
Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients: A Randomized Trial
- Status
- Terminated
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 362 (actual)
- Sponsor
- CRG UZ Brussel · Academic / Other
- Sex
- Female
- Age
- 18 Years – 42 Years
- Healthy volunteers
- Not accepted
Summary
The aim of the current study is to compare miscarriage rates (before 8 weeks) between a true natural cycle (awaiting spontaneous LH surge) and a hormone replacement therapy cycle prior to blastocyst transfer in preimplantation genetic testing (PGT) patients, with biopsy on day 5 of embryonic development. The advantage of performing the study in PGT patients is the exclusion of aneuploidy as a cause of miscarriage.
Conditions
- Miscarriage
- Frozen Embryo Transfer
- Natural Cycle
- Hormone Replacement Therapy Cycle
- Preimplantation Genetic Screening
- Euploid Embryos
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Estradiol Valerate | Estradiol valerate will be started in the beginning of the menstrual cycle in order to induce proliferation of the endometrium. |
| DRUG | Micronized progesterone | If the endometrium is considered adequately proliferated, micronized progesterone is administered and frozen-thawed blastocyst transfer will take place on the 6th day of supplementation. |
Timeline
- Start date
- 2019-05-25
- Primary completion
- 2025-01-01
- Completion
- 2025-01-01
- First posted
- 2019-06-06
- Last updated
- 2025-01-28
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT03976544. Inclusion in this directory is not an endorsement.