Trials / Completed

CompletedNCT03974321

Intraoperative Hypotension and Perioperative Myocardial Injury

Association Between Intraoperative Hypotension and Perioperative Myocardial Injury: a Nested Case Control Study

Status: Completed
Phase: —
Study type: Observational
Enrollment: 600 (actual)

Sponsor: Karolinska Institutet · Academic / Other
Sex: All
Age: 18 Years
Healthy volunteers: Accepted

Summary

Acute myocardial infarction (MI) is a significant complication following non-cardiac surgery. We sought to evaluate incidence of perioperative MI, its preoperative - and intraoperative - risk factors and outcomes after this complication.

Detailed description

Background: In Sweden, over 800 000 patents undergo surgery each year. Worldwide, the number of surgical procedures yearly is over 310 million. Surgical care is en essential part of the advancement in treating disease, associated with increased lift expectancy a d improved quality of life. However as surgical volume continues to grow, the number of patients who suffer postoperative complications will also increase. Hemodynamic instability in the perioperative period is frequent and there has been a cumulative interest in this area and the relation to organ failure over the recent years. There are several studies showing results of associations between intraoperative hypotensive events and perioperative cardiac, kidney and cerebral injury, as well as increased mortality in high-risk surgical patients. More specifically the project aims to answer how intraoperative events, with a special focus on hypotension, are related to perioperative myocardial and kidney injury. We hypothesize that patients, with preoperative risk factors, undergoing major non-cardiac surgery are at increased risk of developing perioperative organ damage in the presence of intraoperative hypotension or other events such as tachycardia, hypoxia and extensive blood loss.

Conditions

Timeline

Start date: 2019-05-01
Primary completion: 2019-06-15
Completion: 2020-03-30
First posted: 2019-06-04
Last updated: 2020-10-26

Locations

1 site across 1 country: Sweden

Source: ClinicalTrials.gov record NCT03974321. Inclusion in this directory is not an endorsement.