NCT03973749

Effects of a High or Low Salycilate Diet on Urinary LTE4 and Clinical Features in AERD

Effects of a High or Low Salycilate Diet on Urinary Leucotriene E4 Levels and Clinical Features in Patients With Aspirin Exacerbated Respiratory Disease

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Instituto Nacional de Enfermedades Respiratorias · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

On day one, two groups of nine patients each will respectively recieve the tree daily meals (breakfast, Lunch and dinner) in a controled clinical setting. Group 1 will recieve a low-salycilate diet, and group 2 a high-salycilate diet. Two hours after each meal, urinary Leucotriene E4, FEV1, FVC, FEV1/FVC and total nasal resistance will be measured. On day 7, after clearance time, group 1 will recieve high-salycilate diet and group 2 low salycilate diet and the same measurements will be obtained.

Conditions

• Aspirin-exacerbated Respiratory Disease
• Aspirin-Sensitive Asthma With Nasal Polyps
• Samter's Syndrome
• Widal Syndrome

Interventions

Type	Name	Description
OTHER	Low salycilate diet	Each arm of the experimental group will be exposed to low and high concentrations of dietary salycilates and urinary LTE4, FEV1, FVC, FEV1/FVC and total inspiratory nasal resistance will be measured at basal level and then two hours after each of the 3 daily meals.

Timeline

• Start date: 2017-02-02
• Primary completion: 2019-05-31
• Completion: 2019-05-31
• First posted: 2019-06-04
• Last updated: 2019-06-04

Locations

1 site across 1 country: Mexico