NCT03973710

Effect of Probiotics on Blood Pressure Management

Role of Probiotics in the Prevention of Hypertension

• Status: Suspended
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Dysbiosis of gut microbiota has been reported to be involved in the development and progression of hypertension in both humans and animal models. Probiotics have been reported to have ameliorative effects in murine models. However, whether probiotics could help alleviate hypertension in adults remain obscure.

Detailed description

Probiotics are live microorganisms that have been associated with multiple health benefits. However, its protective role in adults has long been controversial. This study aims to examine the effect of 12-week probiotics supplementation on the prevention of hypertension in Chinese adults. By understanding the mechanisms by which probiotics exert this beneficial effects, we can better control the rising prevalence of hypertension, which is a major risk factor for cardiovascular diseases.

Conditions

• Hypertension

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Lactobacillus paracasei dietary supplement	a commercial probiotic dietary supplement
DIETARY_SUPPLEMENT	Placebo controls	placebo with a similar appearance to probiotics supplement

Timeline

• Start date: 2022-06-03
• Primary completion: 2023-03-31
• Completion: 2023-12-31
• First posted: 2019-06-04
• Last updated: 2022-05-09

Locations

1 site across 1 country: China