NCT03971955

CharacterIzation of Adult Onset Autoimmune Diabetes

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 25 (actual)
• Sponsor: AdventHealth Translational Research Institute · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to identify new biomarkers of Adult Onset Autoimmune Diabetes (AOnAD).

Conditions

• Diabetes

Interventions

Type	Name	Description
OTHER	Mixed Meal Test	a standard liquid mixed meal will be administered to the participant. The test meal with 1 kcal/ml and with the following caloric distribution Protein: 25%, Carbohydrate: 53%, Fat: 22% is given at a dose of 6 mL per kilogram body weight. Maximum dose is 360 mL and it will be ingested over 5 minutes. Blood samples will be taken 10 min prior to ingestion (t=-10), at baseline (t = 0), and at 15, 30, 60, 90, and 120 minutes.
OTHER	Dual Energy X-Ray Absorptiometry (DEXA)	DEXA Scans will be performed to obtain body composition measures (body fat and estimated muscle mass) using a General Electric (GE) Lunar iDXA whole-body scanner.
PROCEDURE	Adipose Tissue Biopsy	The abdominal skin 6-10 cm lateral to the umbilicus will be cleansed with chlorhexidine. A sterile drape is placed, and the skin and adipose tissue will be anesthetized using Lidocaine. A 3-4 mm Mercedes Liposuction cannula will be inserted for aspiration of up to 2g of adipose tissue.

Timeline

• Start date: 2019-07-08
• Primary completion: 2021-11-12
• Completion: 2026-12-01
• First posted: 2019-06-03
• Last updated: 2026-03-30

Locations

1 site across 1 country: United States