NCT03967340

PREdiction of Chronic LUng Allograft Dysfunction

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 240 (actual)
• Sponsor: Nantes University Hospital · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

Chronic lung allograft dysfunction (CLAD) is the leading cause of long-term mortality after lung transplantation. Several risk factors for CLAD have been identified, but the exact pathophysiology and triggering molecular factors remain largely unknown. Moreover, in clinical practice, no integration of the different risk factors is achieved. CLAD is therefore diagnosed most often late with the persistent decline in respiratory function, revealing a profound and irreversible alteration of the pulmonary graft. Several blood biomarkers that can predict the occurrence of CLAD more than 6 months before clinical diagnosis have been identified and validated. From these preliminary results, a composite score is being developed from independent samples from the COLT (COhort in Lung Transplantation) cohort. The main objective of this project is to validate this robust and predictive composite score (biological and clinical) of CLAD.

Conditions

• Lung Transplant Rejection

Timeline

• Start date: 2020-09-10
• Primary completion: 2027-03-01
• Completion: 2027-03-01
• First posted: 2019-05-30
• Last updated: 2025-05-16

Locations

10 sites across 1 country: France