NCT03965429

Immunological Follow-up After Allogeneic Hematopoietic Stem Cell Transplantation

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,020 (estimated)
• Sponsor: Institut Paoli-Calmettes · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Description of the evolution of the biological characteristics of immune blood populations and biomarkers of interest in patients who have received allogeneic hematopoietic stem cell transplantation.

Detailed description

a more in-depth analysis of the different immune cell sub-populations as well as serum markers (cytokines) would provide a better understanding of post-allograft immune reconstitution mechanisms and identify potential immunologic biomarkers predictive of GVH or relapse.

Conditions

• Malignant Hemopathy

Interventions

Type	Name	Description
OTHER	Blood samples (additional tubes from care) longitudinal	Some sampling times will be systematic, while others will only be performed in the presence of specific post-transplant clinical events (eg relapse, GVH ...).
OTHER	Blood samples (additional tubes from care) at inclusion	In the case of a transplant from an intrafamily donor (genoid or haploid), we will also collect blood samples from the donor. A single blood sample of 28 mL (7 EDTA tubes) will be made. In order not to represent an additional sample for the donor, this sample will be taken before the mobilization of the hematopoietic stem cells, during the biological assessment required for the biological donation qualification.

Timeline

• Start date: 2019-05-14
• Primary completion: 2029-05-14
• Completion: 2029-05-31
• First posted: 2019-05-29
• Last updated: 2025-06-15

Locations

1 site across 1 country: France