NCT03964909

Resting-State Functional MRI in Glioma Patients Before and After Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 29 (actual)
• Sponsor: M.D. Anderson Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial studies how well resting-state functional magnetic resonance imaging (MRI) and cerebrovascular reactivity (CVR) MRI performed before and after surgery works in measuring the effects on language in patients with glioma. Mapping language function before brain tumor resection is crucial for preventing post-surgical deficits and maximizing restoration of language function following surgery. Additional imaging, such as resting-state functional MRI and CVR MRI, may help measure the language network in the brain before surgery and any effects on language function after surgery.

Detailed description

PRIMARY OBJECTIVES: I. To develop a reliable platform for preoperative mapping of language networks using resting-state-functional magnetic resonance imaging (rs)-fMRI in glioma patients. SECONDARY OBJECTIVES: I. To explore the reorganizations of resting-state functional connectivity (FC) and their relation to neuropsychological outcomes in glioma patients after surgery. OUTLINE: Patients undergo standard of care functional (f)MRI, CVR MRI over 3 minutes, and rs-fMRI over 6 minutes 1 month before and within 6 weeks after standard of care surgery. After completion of study, patients are followed up at 4-6 weeks.

Conditions

• Brain Mass
• Glioma

Interventions

Type	Name	Description
PROCEDURE	Functional Magnetic Resonance Imaging	Undergo fMRI
PROCEDURE	Magnetic Resonance Imaging	Undergo CVR MRI
PROCEDURE	Resting State Functional Connectivity Magnetic Resonance Imaging	Undergo rs-fMRI

Timeline

• Start date: 2017-04-24
• Primary completion: 2024-11-12
• Completion: 2024-11-12
• First posted: 2019-05-28
• Last updated: 2024-11-15

Locations

1 site across 1 country: United States