NCT03964779

Prevalence of Thyroid Dysfunction and Anti-thyroid Antibodies in Infertile Women

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 120 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: Female
• Age: 20 Years – 40 Years
• Healthy volunteers: —

Summary

The study population will be divided into three groups: * Group (A) consisting of 40 infertile women with either unexplained or anovulatory infertility with/without associated male factor of infertility, * Group (B) consisting of 40 infertile women with tubal (mechanical) factor of infertility with/without associated male factor of infertility, and * Group (C) consisting of 40 women with exclusive male factor of infertility and will be used as a control group. . All women will be subjected to: * Informed consent * Full history taking, including age, duration of infertility and whether primary or secondary * General and pelvix examination * Trans-vaginal ultrasonography * Determination of hormonal profile (FSH, LH, Estradiol, Prolactin) * Determination of ovulatory status * Determination of of tubal patency * Determination of presence of male factor * Determination of TSH and antithyroid antibodies (antithyroglobulin and antithyroid peroxidase) blood levels

Detailed description

The study population will be divided into three groups: * Group (A) consisting of 40 infertile women with either unexplained or anovulatory infertility with/without associated male factor of infertility, * Group (B) consisting of 40 infertile women with tubal (mechanical) factor of infertility with/without associated male factor of infertility, and * Group (C) consisting of 40 women with exclusive male factor of infertility and will be used as a control group. . All women will be subjected to: * Informed consent * Full history taking, including age, duration of infertility and whether primary or secondary * General and pelvix examination * Trans-vaginal ultrasonography * Determination of hormonal profile (FSH, LH, Estradiol, Prolactin) * Determination of ovulatory status (by previous documented history of induction of ovulation OR previous ultrasonography OR previous estimation midluteal serum progesterone, etc …) * Determination of of tubal patency (by previous hysterosalpingiography or laparoscopy) * Determination of presence of male factor (by seminal fluid analysis) * Determination of TSH and antithyroid antibodies (antithyroglobulin and antithyroid peroxidase) blood levels

Conditions

• Infertility, Female

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Hormonal assay	Measurement of Thyroid stimulating hormone
DIAGNOSTIC_TEST	Antibody assay	antithyroglobulin and antithyroid peroxidase

Timeline

• Start date: 2019-05-01
• Primary completion: 2019-12-01
• Completion: 2020-01-01
• First posted: 2019-05-28
• Last updated: 2019-05-28

Locations

1 site across 1 country: Egypt