NCT03961464

The Effect of D-cycloserine on Emotional Processing

The Effect of NMDA Receptor Partial Agonist D-cycloserine on Emotional Processing, Stress and Memory in Healthy Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Oxford · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

To investigate the effects of N-methyl-D-aspartate (NMDA) partial agonist DCS on emotional processing, memory and stress tasks

Detailed description

The aim of the present study is to assess the effect of DCS on emotional processing relevant to antidepressant drug activity. For this, 40 healthy volunteers will be recruited to the study and randomized to receive a single session of 250mg DCS or placebo. 3 hours and 24 hours after active drug/placebo administration, the effects of emotional processing via the use of cognitive tasks will be assessed. Also, given the important role of DCS in memory and stress, we also include tasks to explore changes in autobiographical memory and in psychological and physiological measures of stress and arousal.

Conditions

• Cycloserine
• Healthy Volunteer

Interventions

Type	Name	Description
DRUG	d-cycloserine	Single dose
DRUG	Placebo	Single dose

Timeline

• Start date: 2018-08-10
• Primary completion: 2018-12-05
• Completion: 2018-12-05
• First posted: 2019-05-23
• Last updated: 2019-05-23

Locations

1 site across 1 country: United Kingdom