NCT03960411

Effect of Doxycycline on Cardiac Remodelling in STEMI Patients

Effect of Doxycycline on Cardiac Remodelling in Patients With ST-Elevation Myocardial Infarction (STEMI)

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Felix Chikita Fredy, MD · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Subsequent to the loss of myocardium post-myocardial infarction (MI), the affected ventricle undergoes some dynamic structural and functional changes known as remodeling. Cardiac remodeling progresses into heart failure (HF). In this revolutionized percutaneous coronary intervention (PCI) era, the incidence of post-MI HF due to cardiac remodeling remains high. Current standard therapeutic interventions, for HF, aimed solely at correcting a low cardiac output do not necessarily impede HF progression. Recently, doxycycline was found to have an additional biological effect aside from their antimicrobial actions. From several experimental studies and clinical trials, doxycycline showed MMP inhibition activities that can prevent ventricular remodeling. This study aims to evaluate the role of doxycycline in cardiac remodeling prevention post-MI. Our hypothesis is that a better heart function will be observed in STEMI patients who receive a short period of doxycycline administration post-PCI.

Conditions

• ST Elevation Myocardial Infarction
• Anterior Wall Myocardial Infarction
• Heart Failure
• Remodeling, Ventricular

Interventions

Type	Name	Description
DRUG	Doxycycline 100Mg Capsule	Doxycycline capsule
DRUG	Placebo oral capsule	Capsule manufactured to mimic doxycycline 100 mg capsule

Timeline

• Start date: 2019-05-25
• Primary completion: 2019-08-01
• Completion: 2019-11-01
• First posted: 2019-05-23
• Last updated: 2019-08-06

Locations

1 site across 1 country: Indonesia