NCT03958734

Postprandial Monocyte Maturation and Vascular Dysfunction Following High-Fat Meals - Study 1

Postprandial Monocyte Maturation and Vascular Dysfunction Following High-Fat Meals: The Impact of Cardiovascular Fitness and Acute Aerobic Exercise - Study 1

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 59 (actual)
• Sponsor: Virginia Commonwealth University · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research study is to examine the effect of high-fat meals on the health of blood vessels. In addition, the study will examine how exercise/fitness/physical activity impacts blood vessels after consumption of a high-fat meal.

Detailed description

This is the first in a series of studies examining the impact of high-fat meals on blood vessels. During the preliminary visit of this study, eligible participants' resting metabolic rate, arm flow mediated dilation, and leg flow mediate dilation will be measured. They will complete handgrip and plantar flexion exercise tasks. Finally, they will be given a physical activity monitor to wear for 7 days. At their first visit, participants will eat a high-fat meal and blood will be drawn to measure blood vessel health. They will also repeat the arm flow mediated dilation, leg flow mediate dilation, handgrip, and plantar flexion exercise tests.

Conditions

• Cardiovascular Risk Factor
• Lipemia

Interventions

Type	Name	Description
OTHER	High-fat meal	Participants will be given a serving of Marie Callendar's Chocolate Satin Pie to eat over a period of 20 minutes

Timeline

• Start date: 2019-06-17
• Primary completion: 2021-04-29
• Completion: 2021-04-29
• First posted: 2019-05-22
• Last updated: 2022-04-13

Locations

1 site across 1 country: United States