Trials / Unknown
UnknownNCT03955497
Effectiveness of Autologous Adipose-derived Stem Cells in the Treatment of Knee Cartilage Injury
Efficacy and Safety Research of Autologous Adipose-derived Mesenchymal Stem Cell Gel in the Treatment of Cartilage Damage in the Knee
- Status
- Unknown
- Phase
- Phase 1 / Phase 2
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- Sponsor
- Qilu Hospital of Shandong University · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
This study was aimed to evaluate the efficacy and safety of Autologous Adipose-derived Mesenchymal Stem Cell Gel combine with High tibial osteotomy therapy in the treatment of cartilage damage in the knee. Investigator believe that this method will enable patients to recover better knee function and more repair of knee cartilage.
Detailed description
The patients who will underwent high tibial osteotomy were randomly divided into the experimental group and the control group. Abdominal fat extraction before operation in experimental group to prepare Adipose-derived Mesenchymal Stem Cell Gel, while the control group only underwent high tibial osteotomy. One month after operation, the experimental group was injected with Adipose-derived Mesenchymal Stem Cell Gel into the joint cavity, and the control group was injected with sodium hyaluronate in the joint cavity. Two groups of patients were followed up.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Autologous Adipose-derived Mesenchymal Stem Cell Gel | The experimental group received intra-articular injection of Autologous Adipose-derived Mesenchymal Stem Cell Gel one month after operation. |
| DRUG | Sodium Hyaluronate | The control group received intra-articular injection of sodium hyaluronate one month after operation. |
| PROCEDURE | Extraction of abdominal fat | In the experimental group, abdominal fat was extracted before operation to prepare Autologous Adipose-derived Mesenchymal Stem Cell Gel. |
Timeline
- Start date
- 2018-10-01
- Primary completion
- 2022-10-01
- Completion
- 2022-12-01
- First posted
- 2019-05-20
- Last updated
- 2020-09-16
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT03955497. Inclusion in this directory is not an endorsement.