NCT03954405

Multi-marker Approach for Risk Assessment in PAH

Multi-marker Approach for Risk Assessment in Pulmonary Arterial Hypertension (PAH)

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Wuhan Asia Heart Hospital · Academic / Other
• Sex: All
• Age: 1 Year – 85 Years
• Healthy volunteers: Not accepted

Summary

Prospective registry including incident patients and prevalent patients which pretends to identify clinical characteristics, treatment trends in-hospital and ten years follow-up outcome through major adverse cardiovascular events (MACE) in a China population with well characterized PAH.

Detailed description

baseline include: An echocardiogram to assess the size, shape, pumping action and the extent of any damage to the heart. Lung function tests which include blowing measurements to assess gas volumes within the lungs as well as assessment of how the lungs exchange gases. Right heart catheterisation (RHC) to diagnose PAH Optional Cardiac Magnetic Resonance tests. 6 minute walk distance (6MWD). To measure exercise capacity Electrocardiogram (ECG), a test that measures the electrical activity of the heart Blood tests MACE include: death heart/lung transplantation atrial septostomy hospitalization due to worsening of PAH start of new specific PAH treatment persistent decrease of \>15% from baseline in 6MWD (or \>30% compared with last study-related measurement) persistent worsening of World Health Organization (WHO) Functional Class (FC）

Conditions

• Pulmonary Arterial Hypertension

Timeline

• Start date: 2017-11-01
• Primary completion: 2023-12-30
• Completion: 2025-12-30
• First posted: 2019-05-17
• Last updated: 2021-04-13

Locations

1 site across 1 country: China