NCT03951896

Efficacy of Platelet Rich Plasma Injections in Patients With Adhesive Capsulitis of the Shoulder

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Ege University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study was done to investigate whether platelet rich plasma(PRP) injections are effective in the management of adhesive capsulitis of the shoulder(AC).Patients were randomized to 2 groups, and one group took PRP injections for 3 times every two weeks, while the other group took saline injections in same frequency and volume. A standardized exercise programme was also applied to all patients. Patients were then evaluated with Shoulder Pain and Disability Index(SPADI), Visual analogous scales for pain and disability, Ranges of Movements and use of analgesics in before, after and 3rd month of the therapy.

Conditions

• Adhesive Capsulitis of Shoulder
• Adhesive Capsulitis
• Frozen Shoulder

Interventions

Type	Name	Description
BIOLOGICAL	PRP	A venous blood sample of 8.5 ml were obtained from all patients. For the treatment group, the blood samples were treated with 1.5 ml ACD-A or sodium citrate to achieve anticoagulation. The blood was then centrifugated for 5 minutes with RCF 1200 G velocity to clump red blood cells, and then centrifugated for 10 minutes in same velocity to obtain platelet concentrate. 2 ml's of the resulting platelet rich plasma was injected to the shoulder of the subjects.All of the injections were done every two weeks, for a total of 3 times using 21 G injection needles with injection technique of posterior approach.
OTHER	Saline injection	2 ml's of NaCl solution with 0,9% concentration was applied to the shoulders of the participants.

Timeline

• Start date: 2014-05-03
• Primary completion: 2015-09-04
• Completion: 2015-09-04
• First posted: 2019-05-16
• Last updated: 2019-05-16