NCT03950245

Incretin Hormone Antagonism After Bariatric Surgery

Importance of Endogenous Glucagon-like Peptide-1 and Glucose-dependent Insulinotropic Polypeptide for Postprandial Glucose Metabolism After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Hvidovre University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Using the glucagon-like peptide-1 (GLP-1) antagonist exendin(9-39) and the glucose-dependent insulinotropic peptide (GIP) antagonist GIP(3-30), the purpose of this study is to clarify the importance of endogenous GLP-1 and GIP for postprandial glucose metabolism after RYGB and SG in subjects with normal glucose tolerance. We hypothesize that GLP-1 is more important after RYGB, and GIP is more important after SG, for postprandial glucose tolerance and beta-cell function. A group of un-operated subjects with normal glucose tolerance will serve as controls.

Conditions

• Bariatric Surgery

Interventions

Type	Name	Description
OTHER	Placebo	Four-hour liquid mixed meal tests and a subsequent ad libitum meal during saline infusion.
OTHER	GLP-1 antagonism	Four-hour liquid mixed meal tests and a subsequent ad libitum meal during exendin 9-39 and saline infusion.
OTHER	GIP antagonism	Four-hour liquid mixed meal tests and a subsequent ad libitum meal during GIP(3-30) and saline infusion.
OTHER	GLP-1 and GIP antagonism	Four-hour liquid mixed meal tests and a subsequent ad libitum meal during exendin and GIP(3-30) infusion.

Timeline

• Start date: 2019-07-01
• Primary completion: 2021-04-16
• Completion: 2021-04-16
• First posted: 2019-05-15
• Last updated: 2022-02-01

Locations

2 sites across 1 country: Denmark