NCT03949036

Comparison of Two Different Preload Targets of Stroke Volume Variation During Kidney Transplantation

Comparison of Two Different Preload Targets of Stroke Volume Variation During Kidney Transplantation: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

The investigators sought to compare the effect of two preload targets of stroke volume variation of ≤6% and ≤12% on the postoperative renal function in patients undergoing living donor kidney transplantation. Goal-directed fluid therapy will be performed in both groups to maintain adequate stroke volume, stroke volume variation, mean arterial pressure (or systemic vascular resistance) during kidney transplantation. Only the preload target for giving crystalloid during surgery will be different between groups.

Detailed description

The adequate preload target of fluid management has not yet been established during kidney transplantation. Traditionally, sufficient intravascular volume status has been recommended to maintain perfusion to renal graft. Stroke volume variation was reported to be superior to the traditional target of central venous pressure. In this regard, the investigators sought to compare the effect of two preload targets of stroke volume variation of ≤6% and ≤12% on the postoperative renal function in patients undergoing living donor kidney transplantation. Goal-directed fluid therapy will be performed in both groups to maintain adequate stroke volume, stroke volume variation, mean arterial pressure (or systemic vascular resistance) during kidney transplantation. Only the preload target for giving crystalloid during surgery will be different between groups.

Conditions

• Kidney Transplant; Complications
• Renal Failure Chronic

Interventions

Type	Name	Description
OTHER	Crystalloid fluid administration with the target of stroke volume variation ≤ 12%	The rate of crystalloid fluid administration will be controlled to achieve the target of stroke volume variation ≤ 12%
OTHER	Crystalloid fluid administration with the target of stroke volume variation ≤ 6%	The rate of crystalloid fluid administration will be controlled to achieve the target of stroke volume variation ≤ 6%

Timeline

• Start date: 2019-05-01
• Primary completion: 2020-11-25
• Completion: 2020-11-25
• First posted: 2019-05-14
• Last updated: 2021-10-21

Locations

1 site across 1 country: South Korea