NCT03945305

Safety and Efficacy of Remote Ischemic Conditioning Treatment for Community-based Essential Hypertension

Safety and Efficacy of Remote Ischemic Conditioning Treatment for Community-based Essential Hypertension: a Randomized, Parallel-controlled Clinical Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 500 (estimated)
• Sponsor: Yi Yang · Academic / Other
• Sex: All
• Age: 40 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to explore the efficacy and safety of remote ischemic conditioning for essential hypertension in the community population.

Detailed description

At present, stroke has become the leading cause of death in China, with hypertension being the primary risk factor and one of the controllable risk factors. Current studies have shown that remote ischemic conditioning can improve vascular endothelial function, inhibit sympathetic nervous system activity and regulate immune and inflammatory reactions. Thus it may exert anti-hypertensive effects through multiple mechanisms. The purpose of this study is to investigate the efficacy and safety of remote ischemic conditioning for essential hypertension in the community population.

Conditions

• Essential Hypertension

Interventions

Type	Name	Description
DEVICE	Patients are treated with previous antihypertensive treatment plus remote ischemic conditioning.	Remote ischemic conditioning (RIC) is induced by 4 cycles of 5 min of upper limb ischemia followed by 5 min reperfusion. Limb ischemia was induced by inflation of a blood pressure cuff to 200 mmHg.
OTHER	Previous antihypertensive treatment	Patients are only treated with previous antihypertensive treatment.

Timeline

• Start date: 2023-11-01
• Primary completion: 2024-03-31
• Completion: 2024-04-28
• First posted: 2019-05-10
• Last updated: 2024-02-28

Locations

1 site across 1 country: China