NCT03938662

S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease

Randomised Controlled Trial Assessing the Effect of S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 44 (estimated)
• Sponsor: University Clinic Dr Dragisa Misovic-Dedinje · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study will assess the effect of treatment with formulation containing S-Adenosyl methionine and choline, on patients with alcoholic liver disease. Half of the patients included will receive named formulation once daily for 24 weeks while other half will receive placebo.

Detailed description

Choline and S-Adenosyl methionine are nutrients both showing hepatoprotective effects. Choline helps liver metabolise glucose and lipids and repair cell membrane. S-Adenosyl methionine is essential for the synthesis of glutathione, a main cellular antioxidant showing its protective effect against free radicals, among others in liver tissue. Furthermore S-Adenosyl methionine is involved in regulation of hepatocyte growth, differentiation, and death. It also enables endogenous production of small amount of choline. Although human organism has capacity for production of small amount of S-Adenosyl methionine, damaged liver can not produce it or produce it insufficient amounts. Having this in mind it can be hypothesised that administration of choline and S-Adenosyl methionine can be beneficial in patients with alcoholic liver disease.

Conditions

• Alcoholic Liver Diseases

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	formulation containing S-Adenosyl methionine and choline	Patients will be administered with formulation containing S-Adenosyl methionine and choline once daily for the period of 24 weeks.
DIETARY_SUPPLEMENT	Placebo	Placebo of same appearance, colour and taste,

Timeline

• Start date: 2019-05-09
• Primary completion: 2020-04-01
• Completion: 2020-04-01
• First posted: 2019-05-06
• Last updated: 2019-05-29

Locations

1 site across 1 country: Serbia