NCT03937661

Autologous Platelet-Rich Plasma Intra-ovarian Infusion in Poor Responders

Investigating Improvement of Ovarian Function Following Autologous PRP Intra-ovarian Infusion in Poor Responders

• Status: Recruiting
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Genesis Athens Clinic · Academic / Other
• Sex: Female
• Age: 35 Years – 47 Years
• Healthy volunteers: Accepted

Summary

Autologous PRP intra ovarian infusion may improve ovarian response, patients' hormonal profile as well as fresh embryo transfer (ET)-ICSI cycles' outcome in patients presenting with Poor Ovarian Response (POR).

Detailed description

This triple-blind Randomized Controlled Trial (RCT) aims to investigate the effectiveness of autologous PRP intra ovarian infusion on improving ovarian tissue functionality and fresh ET-ICSI cycles' performance in regard to patients presenting with POR. PRP is blood plasma prepared from fresh whole blood that has been enriched with platelets. It is collected from peripheral veins and contains several growth factors such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), platelet derived growth factor (PDGF), transforming growth factor (TGF) and other cytokines all of which stimulate tissue proliferation and growth. PRP has been employed in several medical conditions in Orthopedics, Dermatology, and Ophthalmology for wound healing. It's efficacy in ovarian rejuvenation and reactivation and endometrial regeneration has not been fully elucidated. This study aims to investigate the effect of autologous PRP intra ovarian infusion on improving ovarian tissue functionality in POR patients.

Conditions

• Ovary; Anomaly
• Infertility, Female

Interventions

Type	Name	Description
BIOLOGICAL	PRP	Autologous PRP intra ovarian infusion
BIOLOGICAL	Placebo	Autologous PFP intra ovarian infusion

Timeline

• Start date: 2019-05-06
• Primary completion: 2025-01-30
• Completion: 2025-08-30
• First posted: 2019-05-06
• Last updated: 2024-12-27

Locations

1 site across 1 country: Greece