NCT03936166

A Single and Multiple-Ascending Dose Study of CRN01941 in Healthy Adult Volunteers

A Double-Blind, Randomized, Placebo-Controlled, Single- And-Multiple-Ascending Dose Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of CRN01941 in Healthy Volunteers

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 57 (actual)
• Sponsor: Crinetics Pharmaceuticals Inc. · Industry
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

This is a Phase 1, double-blind, randomized, placebo-controlled, single-dose and multiple-dose study of CRN01941 in up to 119 healthy male and female subjects. This single-center study will be conducted in 3 parts: a single-ascending dose phase (up to 8 cohorts, 8 subjects/cohort), a multiple-ascending dose phase (up to 5 cohorts, 9 subjects/cohort), and single dose phase in elderly subjects (1 cohort, 10 subjects).

Conditions

• Healthy Volunteers

Interventions

Type	Name	Description
DRUG	CRN01941 Oral Solution	Investigational drug
DRUG	CRN01941 Oral Capsule	Investigational drug
DRUG	Placebo Oral Solution	Placebo
DRUG	Placebo Oral Capsule	Placebo

Timeline

• Start date: 2019-04-29
• Primary completion: 2019-12-16
• Completion: 2019-12-16
• First posted: 2019-05-03
• Last updated: 2020-11-04

Locations

1 site across 1 country: Australia