NCT03934255

Circadian Mechanisms Underlying Non-Dipping Blood Pressure in Blacks

Central and Peripheral Circadian Mechanisms Underlying Non-Dipping Blood Pressure in Blacks

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study seeks to examine central and peripheral circadian mechanisms in Blacks with appropriately dipping systolic blood pressure (blood pressure that dips by at least 10%) compared with non-dipping systolic blood pressure (blood pressure that dips by less than 10%) using a constant routine protocol. Constant routine protocols are commonly used in the field of circadian biology to examine rhythms in biological processes while controlling the entraining effects of light, activity, and diet.

Detailed description

This study will enroll a total of 40 participants (n=20 non-dippers; n=20 dippers) to complete a 30-hour constant routine protocol. Participants will undergo baseline testing that includes anthropometric measurements, clinic blood pressure measurements, completion of self-report questionnaires on sleep and mood, be fitted with an ambulatory blood pressure monitor and actigraphy watch, and be provided with home sleep testing (HST) equipment. Following completion of baseline assessment, eligible participants will be scheduled for the 30-hour constant routine protocol. The 30-hour constant routine protocol will allow for the hourly collection of saliva, collection of buccal cells every 4 hours, and constant monitoring of core body temperature, all of which are primary outcomes in the assessment of central and peripheral circadian clock markers. Amplitude and phase of these outcomes will be assessed in non-dippers versus dippers.

Conditions

• Circadian Rhythm
• Blood Pressure

Interventions

Type	Name	Description
OTHER	Constant Routine Protocol	Constant routine protocols are used in circadian research to examine underlying circadian rhythms in the absence of light, activity, and meals

Timeline

• Start date: 2020-01-01
• Primary completion: 2023-05-01
• Completion: 2023-05-01
• First posted: 2019-05-01
• Last updated: 2023-06-08

Locations

1 site across 1 country: United States