NCT03933930

Comparing the Prognosis of Lactate-directed and Goal-directed Therapy in Hyperthermic Intraperitoneal Chemotherapy.

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Taipei Medical University WanFang Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Hyperthermic intraperitoneal chemotherapy is a major surgery for tumor peritoneal metastasis. For anesthesiologist, the intra-operative fluid control is always a big challenge. We try to compare the prognosis of lactate-directed and goal-directed therapy. We expect to confirm the better prognosis of lactate-directed therapy.

Conditions

• Organ Failure, Multiple

Interventions

Type	Name	Description
OTHER	Lactate-directed therapy	If the lactate level elevates, we transfuse pRBC to increase Hct\>30%. If Hct \>30%, dopamine infusion starts.
OTHER	Goal-directed therapy	If SVV\>15%, transfuse lactate ringer/normal saline alternatively to keep SVV\<15%.

Timeline

• Start date: 2019-05-06
• Primary completion: 2021-05-15
• Completion: 2021-05-15
• First posted: 2019-05-01
• Last updated: 2020-06-04