Trials / Unknown
UnknownNCT03930927
Effect of Self Assembling Peptide on White Spot Lesion
Evaluation of the Re-mineralizing Effect of Biomimetic Self-Assembling Peptides in Post Orthodontic White Spot Lesions Compared to Fluoride-Based Delivery Systems
- Status
- Unknown
- Phase
- EARLY_Phase 1
- Study type
- Interventional
- Enrollment
- 32 (estimated)
- Sponsor
- Raneen Ahmed · Academic / Other
- Sex
- All
- Age
- 12 Years – 22 Years
- Healthy volunteers
- Accepted
Summary
During re-mineralization of white spot lesion, Will biomimetic self-assembling peptides improve the re-mineralizating effect of the post orthodontic white spot lesion compared to fluoride-based delivery systems?
Detailed description
Conservative dentistry no longer prefers the "drill and fill" concept and advocates reversal of lesions via remineralization. . Remineralization is the process of restoring minerals - again, in the form of mineral ions - to the hydroxyapatite latticework structure. It is three-dimensional, and the lost ions must be replaced with ions having the exact same shape, size and the same electrical charge as those lost from the lattice. Fluoride and self-assembling peptides have been used as adjuncts to enhance remineralization.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Self Assembling peptide | enamel regeneration |
| DRUG | remineralizing agent | enamel regeneration |
Timeline
- Start date
- 2019-05-01
- Primary completion
- 2020-10-01
- Completion
- 2021-03-01
- First posted
- 2019-04-29
- Last updated
- 2019-04-29
Source: ClinicalTrials.gov record NCT03930927. Inclusion in this directory is not an endorsement.