NCT03928782

Dose-effect Relationship Between microRNAs in Peripheral Blood and Radiation Injury

Study on Dose-effect Relationship Between Radiation Injury Dose and Expression of Associated microRNAs in Human Peripheral Blood

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 8 (estimated)
• Sponsor: Affiliated Hospital to Academy of Military Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: —

Summary

Rapid and accurate assessment of radiation injury dose is the key to success in early treatment and an urgent issue to be solved in clinical medicine.Researches showed that the expression of the microRNAs in human peripheral blood had much correlation with radiation injury resulted from different dosages of radiation.In this study,acute leukemic patients who will be pretreated by whole-body radiation are taked as the object of study,and biochip technology are adopted to detect the expression levels of the microRNAs in subject peripheral blood before-and-after radiation,and different expression is tested and Bioinformatics prediction,to evaluate the correlation between radiation injury dose and expression levels of the microRNAs in human peripheral blood.

Conditions

• Radiation Injuries, Experimental

Interventions

Type	Name	Description
RADIATION	5 Gy or 10 Gy units of whole-body radiation	8 subjects will be received 5 Gy units of whole-body radiation or 10 Gy units of whole-body radiation.

Timeline

• Start date: 2018-12-01
• Primary completion: 2019-07-01
• Completion: 2019-09-01
• First posted: 2019-04-26
• Last updated: 2019-04-26

Locations

2 sites across 1 country: China