NCT03927118

Effect of Dexamethasone Implant on Optic Disc

The Effect of Dexamethasone Implant on Retinal Nerve Fiber and Optic Disc Morphology in Patients With Diabetic Maculopathy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 43 (actual)
• Sponsor: Bulent Ecevit University · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the effect of dexamethasone implant which is an intraocular corticosteroid on the optic nerve fibers. Retinal nerve fiber thicknesses and optic nerve head pitting rates were measured before and 6 months after the injection.

Detailed description

Diabetic macular edema is the most frequent ocular complication of diabetes resulting in irreversible loss of vision if untreated. Dexamethasone implant implant is used to treat macular edema due to diabetes. It stay in the vitreous for 6 months after intravitreal administration. Dexamethasone implant can lead to retinal nerve fiber layer and optic nerve damage by both increasing intraocular pressure and its direct effect on neural tissue during the effective 6-month period.

Conditions

• Glaucoma and Ocular Hypertension
• Diabetic Macular Edema
• Intravenous Drug Usage
• Optic Disk Disorders

Interventions

Type	Name	Description
PROCEDURE	intravitreal dexamethasone implant application	Peripapillary RNFL thickness measurements and colored fundus photographs were compared before and 6 months after intravitreal DEX implant injection. The cup-to-disc ratios of fundus photographs were calculated using the Image-J program.

Timeline

• Start date: 2018-02-01
• Primary completion: 2018-09-01
• Completion: 2019-01-31
• First posted: 2019-04-25
• Last updated: 2019-05-13

Locations

1 site across 1 country: Turkey (Türkiye)