NCT03925233

Breast Cancer Treatment Based on Organ-like Culture

Sensitivity Detection and Drug Resistance Mechanism of Breast Cancer Therapeutic Drugs Based on Organ-like Culture

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Xijing Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Based on the breast cancer organ platform, this experiment establishes a drug sensitivity test method that is closer to the body tumor in breast cancer, provides a basis for the accurate treatment of breast cancer, and discusses the possible mechanism of breast cancer drug resistance.

Conditions

• Breast Cancer Organoids

Interventions

Type	Name	Description
DRUG	Trastuzumab	Trastuzumab Injection
DRUG	Doxorubicin Hydrochloride	Doxorubicin Hydrochloride Injection
DRUG	Epirubicin hydrochloride	Epirubicin hydrochloride injection
DRUG	Fluorouracil	Fluorouracil injection
DRUG	Paclitaxel	Paclitaxel injection
DRUG	Gemcitabine	Gemcitabine injection
DRUG	Cisplatin	Cisplatin injection
DRUG	Recombinant Human Endostatin	Recombinant Human Endostatin Injection
DRUG	Pirarubicin hydrochloride	Pirarubicin hydrochloride injection
DRUG	Pyrrolidine	Pyrrolidine tablets
DRUG	Ixabepilone	Ixapilone Injection
DRUG	Tamoxifen citrate	Tamoxifen citrate tablets
DRUG	Vinorelbine tartrate	Vinorelbine tartrate injection
DRUG	Carboplatin	Carboplatin injection
DRUG	Methotrexate	Methotrexate injection
DRUG	Eribulin mesylate	Eribulin mesylate injection
DRUG	Toremifene citrate	Toremifene citrate tablets
DRUG	Anastrozole	Anastrozole tablets
DRUG	Letrozole	Letrozole tablets
DRUG	Exemestane	Exemestane tablets
DRUG	Fulvestrant	Fulvestrant injection
DRUG	Olaparib	Olapani pill
DRUG	Bevacizumab	Bevacizumab injection
DRUG	Apatinib mesylate	Apatinib mesylate tablets
DRUG	Pattozumab	Pattozumab injection
DRUG	Capecitabine	Capecitabine tablets
DRUG	Ear particles	Ear particles
DRUG	Aidi Injection	Aidi Injection
DRUG	Cyclophosphamide	Cyclophosphamide injection

Timeline

• Start date: 2019-01-02
• Primary completion: 2021-12-15
• Completion: 2021-12-15
• First posted: 2019-04-24
• Last updated: 2019-04-24

Locations

1 site across 1 country: China

Regulatory

• FDA-regulated drug study