NCT03925025

Effectiveness of Calcium Channel Blockade for OP and Carbamate Pesticide Poisoning

Effectiveness of Calcium Channel Blockade for Organophosphorus and Carbamate Pesticide Poisoning - an Open, Pragmatic, 3-arm RCT Repurposing Two Widely Available Licensed Medicines

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 1,728 (actual)
• Sponsor: University of Edinburgh · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates whether the addition of intravenous magnesium sulphate or nimodipine to standard therapy (supportive care plus for all patients atropine and, for OP insecticide poisoned patients, pralidoxime) benefits patients after acute anticholinesterase self-poisoning with OP or carbamate insecticides.

Conditions

• Anticholinesterase Insecticide Poisoning
• Pesticide Poisoning

Interventions

Type	Name	Description
DRUG	Magnesium Sulfate	Treatment in addition to standard therapy
DRUG	Nimodipine	Treatment in addition to standard therapy

Timeline

• Start date: 2020-06-11
• Primary completion: 2025-03-31
• Completion: 2025-04-30
• First posted: 2019-04-23
• Last updated: 2025-10-01

Locations

7 sites across 1 country: Bangladesh